Laboratoire du Dr Gerardo Ferbeyre
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Publications:
  • Igelmann S, Lessard F, Uchenunu O, Bouchard J, Fernandez-Ruiz A, Rowell MC, Lopes-Paciencia S, Papadopoli D, Fouillen A, Ponce KJ, Huot G, Mignacca L, Benfdil M, Kalegari P, Wahba HM, Pencik J, Vuong N, Quenneville J, Guillon J, Bourdeau V, Hulea L, Gagnon E, Kenner L, Moriggl R, Nanci A, Pollak MN, Omichinski JG, Topisirovic I, Ferbeyre G. A hydride transfer complex reprograms NAD metabolism and bypasses senescence. Mol Cell. 2021 Sep 16;81(18):3848-3865.
  • Hébert A, Parisotto M, Rowell MC, Doré A, Fernandez Ruiz A, Lefrançois G, Kalegari P, Ferbeyre G*, Schmitzer AR*. Phenylethynylbenzyl-modified biguanides inhibit pancreatic cancer tumor growth. Sci Rep. 2021 May 10;11(1):9854. *corresponding authors
  • Liu, X., Chai, Y., Liu, G., Su, W., Guo, Q., Lv, X., Gao, P., Yu, B., Ferbeyre, G., Cao, X. & Wan, M. Osteoclasts protect bone blood vessels against senescence through the angiogenin/plexin-B2 axis. Nature Communications 12, 1832, (2021).
  • Olga Moiseeva, Jordan Guillon, Gerardo Ferbeyre. Senescence: A program in the road to cell elimination and cancer. Seminars in Cancer Biology. 2020, https://doi.org/10.1016/j.semcancer. 2020.12.017
  • Alan A. Cohen, Brian K. Kennedy, Ulrich Anglas, Anne M. Bronikowski, Joris Deelen, Frédérik Dufour, Gerardo Ferbeyre, Luigi Ferrucci, Claudio Franceschi, Daniela Frasca, Bertrand Friguet, Pierrette Gaudreau, Vadim N. Gladyshev, Efstathios S. Gonos, Vera Gorbunova, Philipp Gut, Mikhail Ivanchenko, Véronique Legault, Jean-François Lemaître, Thomas Liontis, Guang-Hui Liu, Mingxin Liu, Andrea B. Maier, Otávio T. Nóbrega, Marcel G.M. Olde Rikkert, Graham Pawelec, Sylvie Rheault, Alistair M. Senior, Andreas Simm, Sonja Soo, Annika Traa, Svetlana Ukraintseva, Quentin Vanhaelen, Jeremy M. Van Raamsdonk, Jacek M. Witkowski, Anatoliy I. Yashin, Robert Ziman, Tamàs Fülöp. Lack of consensus on an aging biology paradigm? A global survey reveals an agreement to disagree, and the need for an interdisciplinary framework. Mechanisms of Ageing and Development, Volume 191, 2020, 111316.
  • Lessard F, Saint-Germain E, Mignacca L,Ferbeyre G. SOCS1: phosphorylation, dimerization and tumor suppression. Oncoscience. 2019 Dec 23;6(11-12):386-389. doi: 10.18632/oncoscience.495. eCollection 2019 Nov.
  • Deschênes-Simard X, Rowell MC, Ferbeyre G. Metformin turns off the metabolic switch of pancreatic cancer. Aging (Albany NY). 2019 Dec 12;11(23):10793-10795. doi: 10.18632/aging.102622. Epub 2019 Dec 12.
  • Bury M, Le Calvé B, Lessard F, Dal Maso T, Saliba J, Michiels C, Ferbeyre G*, Blank V*. NFE2L3 Controls Colon Cancer Cell Growth through Regulation of DUX4, a CDK1 Inhibitor. Cell Rep. 2019 Nov 5;29(6):1469-1481.e9. doi: 10.1016/j.celrep.2019.09.087. *corresponding authors
  • Gorgoulis V, Adams PD, Alimonti A, Bennett DC, Bischof O, Bishop C, Campisi J, Collado M, Evangelou K, Ferbeyre G, Gil J, Hara E, Krizhanovsky V, Jurk D, Maier AB, Narita M, Niedernhofer L, Passos JF, Robbins PD, Schmitt CA, Sedivy J, Vougas K, von Zglinicki T, Zhou D, Serrano M, Demaria M. Cellular Senescence: Defining a Path Forward. Cell. 2019 Oct 31;179(4):813-827. doi: 10.1016/j.cell.2019.10.005. Review.
  • Igelmann S, Neubauer HA, Ferbeyre G. STAT3 and STAT5 Activation in Solid Cancers. Cancers (Basel). 2019 Sep 25;11(10). pii: E1428. doi: 10.3390/cancers11101428. Review.
  • Zhou TE, Zhu T, Rivera JC, Omri S, Tahiri H, Lahaie I, Rouget R, Wirth M, Nattel S, Lodygensky G, Ferbeyre G, Nezhady M, Desjarlais M, Hamel P, Chemtob S. The Inability of the Choroid to Revascularize in Oxygen-Induced Retinopathy Results from Increased p53/miR-Let-7b Activity. Am J Pathol. 2019 Aug 17. pii: S0002-9440(19)30665-0. doi: 10.1016/j.ajpath.2019.07.009.
  • Caland L, Labbé P, Mamarbachi M, Villeneuve L, Ferbeyre G, Noly PE, Carrier M, Thorin-Trescases N, Thorin É. Knockdown of angiopoietin-like 2 induces clearance of vascular endothelial senescent cells by apoptosis, promotes endothelial repair and slows atherogenesis in mice. Aging (Albany NY). 2019 Jun 11;11(11):3832-3850. doi: 10.18632/aging.102020
  • Saint-Germain E, Mignacca L, Huot G, Acevedo M, Moineau-Vallée K, Calabrese V, Bourdeau V, Rowell MC, Ilangumaran S, Lessard F*, Ferbeyre G*. Phosphorylation of SOCS1 inhibits the SOCS1-p53 tumor suppressor axis. Cancer Res. 2019 79(13):3306-3319. doi: 10.1158/0008-5472.CAN-18-1503. *corresponding authors
  • Del Toro N, Fernandez-Ruiz A, Mignacca L, Kalegari P, Rowell MC, Igelmann S, Saint-Germain E, Benfdil M, Lopes-Paciencia S, Brakier-Gingras L, Bourdeau V, Ferbeyre G*, Lessard F*. Ribosomal protein RPL22/eL22 regulates the cell cycle by acting as an inhibitor of the CDK4-cyclin D complex. Cell Cycle. 2019 Mar - Apr;18(6-7):759-770. doi: 10.1080/15384101.2019.1593708. *corresponding authors
  • Lopes-Paciencia S, Saint-Germain E, Rowell MC, Ruiz AF, Kalegari P, Ferbeyre G. The senescence-associated secretory phenotype and its regulation. Cytokine. 2019 Feb 15;117:15-22. doi: 10.1016/j.cyto.2019.01.013.
  • Lessard F, Brakier-Gingras L, Ferbeyre G. Ribosomal Proteins Control Tumor Suppressor Pathways in Response to Nucleolar Stress. Bioessays. 2019 Mar;41(3):e1800183. doi: 10.1002/bies.201800183.
  • Deschênes-Simard X, Parisotto M, Rowell MC, Le Calvé B, Igelmann S, Moineau-Vallée K, Saint-Germain E, Kalegari P, Bourdeau V, Kottakis F, Bardeesy N, Ferbeyre G. Circumventing senescence is associated with stem cell properties and metformin sensitivity. Aging Cell. 2019 8(2):e12889. doi: 10.1111/acel.12889.
  • Audrey Hébert, Maxime Parisotto, Gerardo Ferbeyre, Andreea R. Schmitzer. Membrane permeabilization and perturbation induced by alkyl- biguanidium salts. Supramolecular Chemistry.  October 2018. https://doi.org/10.1080/10610278.2018.1535710.
  • Matralis AN, Xanthopoulos D, Huot G, Lopes-Paciencia S, Cole C, de Vries H, Ferbeyre G, Tsantrizos YS. Molecular tools that block maturation of the nuclear lamin A and decelerate cancer cell migration. Bioorg Med Chem. 2018 Oct4. pii:S0968-0896(18)31504-9. doi: 10.1016/j.bmc.2018.10.001.
  • Hulea L, Gravel SP, Morita M, Cargnello M, Uchenunu O, Im YK, Lehuédé C, Ma EH, Leibovitch M, McLaughlan S, Blouin MJ, Parisotto M, Papavasiliou V, Lavoie C, Larsson O, Ohh M, Ferreira T, Greenwood C, Bridon G, Avizonis D, Ferbeyre G, Siegel P, Jones RG, Muller W, Ursini-Siegel J, St-Pierre J, Pollak M, Topisirovic I. Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides. Cell Metab. 2018 Sep 17. pii: S1550-4131(18): 30566-7. doi: 10.1016/j.cmet.2018.09.001.
  • Yan Y, Acevedo M, Mignacca L, Desjardins P, Scott N, Imane R, Quenneville J, Robitaille J, Feghaly A, Gagnon E, Ferbeyre G, Major F. The sequence features that define efficient and specific hAGO2-dependent miRNA silencing guides. Nucleic Acids Res. 2018 Sep 19;46(16): 8181-8196. doi: 10.1093/nar/gky546.
  • Rodier F, Zhou D, Ferbeyre G. Cellular senescence, geroscience, cancer and beyond. Aging (Albany NY). 2018 Sep 7;10(9): 2233-2242. doi: 10.18632/aging.101546.
  • Lessard F, Igelmann S, Trahan C, Huot G, Saint-Germain E, Mignacca L, Del Toro N, Lopes-Paciencia S, Le Calvé B, Montero M, Deschênes-Simard X, Bury M, Moiseeva O, Rowell MC, Zorca CE, Zenklusen D, Brakier-Gingras L, Bourdeau V, Oeffinger M, Ferbeyre G. Senescence-associated ribosome biogenesis defects contributes to cell cycle arrest through the Rb pathway. Nat Cell Biol 2018 Jul;20(7): 789-799. doi: 10.1038/s41556-018-0127-y.
  • McManus FP, Bourdeau V, Acevedo M, Lopes-Paciencia S, Mignacca L, Lamoliatte F, Rojas Pino JW, Ferbeyre G*, Thibault P*. Quantitative SUMO proteomics reveals the modulation of several PML nuclear body associated proteins and an anti-senescence function of UBC9. Sci Rep. 2018 May 17;8(1): 7754. doi: 10.1038/s41598-018-25150-z.  *corresponding authors
  • Saint-Germain E, Mignacca L, Vernier M, Bobbala D, Ilangumaran S, Ferbeyre G. SOCS1 regulates senescence and ferroptosis by modulating the expression of p53 target genes. Aging (Albany NY). 2017 Oct 28. 9(10): 2137-2162. doi: 10.18632/aging.101306.
  • Ferbeyre G. Aberrant signaling and senescence associated protein degradation. Exp Gerontol. 2017 Jun 27. pii: S0531-5565(17)30219-X. doi: 10.1016/j.exger.2017.06.016.
  • Villiard É, Denis JF, Hashemi FS, Igelmann S, Ferbeyre G*, Roy S*. Senescence gives insights into the morphogenetic evolution of anamniotes. Biol Open. Jun 15;6(6):891-896. doi: 10.1242/bio.025809. *corresponding authors
  • Chevrier M, Bobbala D, Villalobos-Hernandez A, Khan MG, Ramanathan S, Saucier C, Ferbeyre G, Geha S, Ilangumaran S. Expression of SOCS1 and the downstream targets of its putative tumor suppressor functions in prostate cancer. BMC Cancer. 2017 Feb 24; 17(1):157. doi: 10.1186/s12885-017-3141-8.
  • Villalobos-Hernandez A, Bobbala D, Kandhi R, Khan MG, Mayhue M, Dubois CM, Ferbeyre G, Saucier C, Ramanathan S, Ilangumaran S. SOCS1 inhibits migration and invasion of prostate cancer cells, attenuates tumor growth and modulates the tumor stroma. Prostate Cancer Prostatic Dis. 2017 Mar;20(1):36-47. doi: 10.1038/pcan.2016.50.
  • Lacraz G, Rakotoarivelo V, Labbé SM, Vernier M, Noll C, Mayhue M, Stankova J, Schwertani A, Grenier G, Carpentier A, Richard D, Ferbeyre G, Fradette J, Rola-Pleszczynski M, Menendez A, Langlois MF, Ilangumaran S, Ramanathan S. Deficiency of Interleukin-15 Confers Resistance to Obesity by Diminishing Inflammation and Enhancing the Thermogenic Function of Adipose Tissues. PLoS One. 2016 Sep 29;11(9):e0162995. doi: 10.1371/journal.pone.0162995. Correction:PMID: 27824945  
  • Bourdeau V, Ferbeyre G. CDK4-CDK6 inhibitors induce autophagy-mediated degradation of DNMT1 and facilitate the senescence antitumor response. Autophagy. 2016 Oct 2;12(10):1965-1966.    
  • Acevedo M, Vernier M, Mignacca L, Lessard F, Huot G, Moiseeva O, Bourdeau V, Ferbeyre G. A CDK4/6-Dependent Epigenetic Mechanism Protects Cancer Cells from PML-induced Senescence. Cancer Res. 2016 76:3252-3264    
  • Mukhopadhyay UK, Cass J, Raptis L, Craig AW, Bourdeau V, Varma S, Gupta SS, Elliott BE, Ferbeyre G. Dataset of STAT5A status in breast cancer. Cytokine (Data Brief.) 2016 Mar 4;7:490-2. doi: 10.1016/j.dib.2016.02.073. eCollection 2016 Jun.  

    Ilangumaran S, Ferbeyre G. Editorial: Cytokines in inflammation, aging, cancer and obesity. Cytokine. 2016 Jun;82:1-3. doi: 10.1016/j.cyto.2016.03.011.   Mukhopadhyay UK, Cass J, Raptis L, Craig AW, Bourdeau V, Varma S, SenGupta S, Elliott BE, Ferbeyre G. STAT5A is regulated by DNA damage via the tumor suppressor p53. Cytokine. 2016 Jun;82:70-9. doi: 10.1016/j.cyto.2016.01.013.
  • Mignacca L, Saint-Germain E, Benoit A, Bourdeau V, Moro A, Ferbeyre G. Sponges against miR-19 and miR-155 reactivate the p53-Socs1 axis in hematopoietic cancers. Cytokine. 2016 Jun;82:80-6. doi: 10.1016/j.cyto.2016.01.015.
  • Yeganeh M, Gui Y, Kandhi R, Bobbala D, Tobelaim WS, Saucier C, Yoshimura A, Ferbeyre G, Ramanathan S, Ilangumaran S. Suppressor of cytokine signaling 1-dependent regulation of the expression and oncogenic functions of p21CIP1/WAF1 in the liver. Oncogene. 2016 Aug 11;35(32):4200-11. doi: 10.1038/onc.2015.485.
  • Moiseeva O, Lopes-Paciencia S, Huot G, Lessard F, Ferbeyre G. Permanent farnesylation of lamin A mutants linked to progeria impairs its phosphorylation at serine 22 during interphase. Aging (Albany NY). 2016 8(2):366-81.
  • Shrivastava S, Mansure JJ, Almajed W, Cury F, Ferbeyre G, Popovic M, Seuntjens J, Kassouf W. The role of HMGB1 in radio-resistance of bladder cancer. Mol Cancer Ther. 2016 15(3) :471-9.
  • Tobelaim WS, Beaurivage C, Champagne A, Pomerleau V, Simoneau A, Chababi W, Yeganeh M, Thibault P, Klinck R, Carrier JC, Ferbeyre G, Ilangumaran S, Saucier C. Tumour-promoting role of SOCS1 in colorectal cancer cells. Sci Rep. 2015 Sep 22;5:14301.
  • Moiseeva O, Lessard F, Acevedo-Aquino M, Vernier M, Tsantrizos YS, Ferbeyre G. Mutant lamin A links prophase to a p53 independent senescence program. Cell Cycle. 2015; 14(15):2408-2421.
  • Cappadocia L, Mascle XH, Bourdeau V, Tremblay-Belzile S, Chaker-Margot M, Lussier-Price M, Wada J, Sakaguchi K, Aubry M, Ferbeyre G, Omichinski JG. Structural and Functional Characterization of the Phosphorylation-Dependent Interaction between PML and SUMO1. Structure. 2015; 23(1):126-38.
  • Deschênes-Simard X, Lessard F, Gaumont-Leclerc MF, Bardeesy N, Ferbeyre G. Cellular senescence and protein degradation: Breaking down cancer. Cell Cycle. 2014, 13(12):1840-58.
  • Vernier M, Ferbeyre G. Complete senescence: RB and PML share the task. Cell Cycle. 2014; Feb 4;13(5).
  • Bourdeau V, Ferbeyre G. Engaging a senescent response to cure leukemia. Nat Med. 2014; 20(2): 123-4.
  • Deschênes-Simard X, Kottakis F, Meloche S, Ferbeyre G. ERKs in Cancer: Friends or Foes? Cancer Res. 2014; 74(2):412-9.
  • Huot G, Vernier M, Bourdeau V, Doucet L, Saint-Germain E, Gaumont-Leclerc MF, Moro A, Ferbeyre G. CHES1/FOXN3 regulates cell proliferation by repressing PIM2 and protein biosynthesis. Mol Biol Cell. 2014; 25(5): 554-65
  • Rajesh K, Papadakis AI, Kazimierczak U, Peidis P, Wang S, Ferbeyre G, Kaufman RJ, Koromilas AE. eIF2α phosphorylation bypasses premature senescence caused by oxidative stress and pro-oxidant antitumor therapies. Aging (Albany NY). 2013; 5(12):884-901.
  • Moiseeva O, Deschênes-Simard X, Pollak M, Ferbeyre G. Metformin, aging and cancer. Aging (Albany NY). 2013; 5(5):330-1.
  • Deschênes-Simard, X., Gaumont-Leclerc, M.F., Bourdeau, V., Moiseeva, O., Forest, V., Ingelman, S., Mallette, F.A., Lessard, F., El-Leil, M.S., Meloche, S., Saad, F., Mes-Masson, AM. and Ferbeyre, G. (2013). Tumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradation. Genes and Dev 27(8):900-15.
  • Moiseeva O, Deschênes-Simard X, St-Germain E, Igelmann S, Huot G, Cadar AE, Bourdeau V, Pollak MN, Ferbeyre G. Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-?B activation. Aging Cell 12(3):489-98.
  • Algire C, Moiseeva O, Deschenes-Simard X, Amrein L, Petruccelli LA, Birman E, Viollet B, Ferbeyre G*, Pollak MN*. (2012). Metformin reduces endogenous reactive oxygen species and associated DNA damage. Cancer Prev Res. 5(4):536-43.*corresponding authors
  • Drogaris P, Villeneuve V, Pomiès C, Lee EH, Bourdeau V, Bonneil E, Ferbeyre G, Verreault A, Thibault P. (2012) Histone deacetylase inhibitors globally enhance h3/h4 tail acetylation without affecting h3 lysine 56 acetylation. Sci Rep. 2:220.
  • Charbonneau J, Gendron K, Ferbeyre G, Brakier-Gingras L. (2012) The 5' UTR of HIV-1 full-length mRNA and the Tat viral protein modulate the programmed -1 ribosomal frameshift that generates HIV-1 enzymes. RNA 18(3):519-29.
  • Gui Y, Yeganeh M, Ramanathan S, Leblanc C, Pomerleau V, Ferbeyre G, Saucier C, Ilangumaran S. (2011). SOCS1 controls liver regeneration by regulating HGF signaling in hepatocytes. J Hepatol. 55(6):1300-8.
  • Perreault J, Weinberg Z, Roth A, Popescu O, Chartrand P, Ferbeyre G, Breaker RR. (2011). Identification of hammerhead ribozymes in all domains of life reveals novel structural variations. PLoS Comput Biol. 7(5):e1002031.
  • Moiseeva O, Bourdeau V, Vernier M, Dabauvalle MC, Ferbeyre G. (2011) Rb-independent regulation of cell proliferation and senescence by the p53-p21 axis in lamin A/C depleted cells. Aging Cell 10(5): 789-97.
  • Boulay PL, Schlienger S, Lewis-Saravalli S, Vitale N, Ferbeyre G, Claing A. (2011) ARF1 controls proliferation of breast cancer cells by regulating the retinoblastoma protein. Oncogene. 30(36): 3846-61.
  • Gendron K, Ferbeyre G, Heveker N, Brakier-Gingras L. (2011). The activity of the HIV-1 IRES is stimulated by oxidative stress and controlled by a negative regulatory element. Nucleic Acids Res. 39(3): 902-12.
  • Vernier M, Bourdeau V, Gaumont-Leclerc MF, Moiseeva O, Bégin V, Saad F, Mes-Masson AM, Ferbeyre G. (2011). Regulation of E2Fs and senescence by PML nuclear bodies. Genes Dev. 25(1):41-50.
  • Ferbeyre G, Moriggl R. (2011). The role of Stat5 transcription factors as tumor suppressors or oncogenes. Biochim Biophys Acta 1815(1):104-14.
  • Mallette FA, Calabrese V, Ilangumaran S, Ferbeyre G. (2010) SOCS1, a novel interaction partner of p53 controlling oncogene-induced senescence. Aging 2(7):445-52.
  • Ferbeyre G. Bile acids in the fountain of youth. (2010) Aging 2(7): 383-4.
  • Mallette FA, Moiseeva O, Calabrese V, Mao B, Gaumont-Leclerc MF, Ferbeyre G. (2010) Transcriptome analysis and tumor suppressor requirements of STAT5-induced senescence. Ann N Y Acad Sci. 1197:142-51.
  • Roux AE, Arseneault G, Chartrand P, Ferbeyre G, Rokeach LA. (2010) A screen for genes involved in respiration control and longevity in Schizosaccharomyces pombe. Ann N Y Acad Sci. 1197:19-27.
  • Ramanathan S, Dubois S, Gagnon J, Leblanc C, Mariathasan S, Ferbeyre G, Rottapel R, Ohashi PS, Ilangumaran S. (2010) Regulation of Cytokine-Driven Functional Differentiation of CD8 T Cells by Suppressor of Cytokine Signaling 1 Controls Autoimmunity and Preserves Their Proliferative Capacity toward Foreign Antigens. J Immunol. 185(1):357-66.
  • De Guire V, Caron M, Scott N, Ménard C, Gaumont-Leclerc MF, Chartrand P, Major F, Ferbeyre G. (2010) Designing small multiple-target artificial RNAs. Nucleic Acids Res. 38(13): e140.
  • Voghel G, Thorin-Trescases N, Mamarbachi AM, Villeneuve L, Mallette FA, Ferbeyre G, Farhat N, Perrault LP, Carrier M, Thorin E. (2010) Endogenous oxidative stress prevents telomerase-dependent immortalization of human endothelial cells. Mech Ageing Dev. 131(5):354-63.
  • Roux AE, Chartrand P, Ferbeyre G, Rokeach LA. Fission Yeast and Other Yeasts as Emergent Models to Unravel Cellular Aging in Eukaryotes. J Gerontol A Biol Sci Med Sci. 2010 Jan;65(1):1-8.
  • Calabrese V, Mallette FA, Deschênes-Simard, X, Ramanathan S, Gagnon J, Moores A, Ilangumaran S, Ferbeyre G. (2009). SOCS1 Links Cytokine Signaling to p53 and Senescence. Mol Cell 36(5):754-767.
  • Moiseeva O, Bourdeau V, Roux A, Deschênes-Simard X, Ferbeyre G. (2009). Mitochondrial dysfunction contributes to oncogene-induced senescence. Mol Cell Biol. 29(16):4495-507.
  • Roux AE, Leroux A, Alaamery MA, Hoffman CS, Chartrand P*, Ferbeyre G*, Rokeach LA*. (2009). Pro-Aging Effects of Glucose Signaling through a G Protein-Coupled Glucose Receptor in Fission Yeast. PLoS Genet. Mar;5(3):e1000408.*corresponding authors
  • Gaumont-Leclerc MF, Ferbeyre G. (2009). Cytokines prevent tumors via a cell senescence mechanism. Med Sci (Paris) 25(2):138-40. French.
  • Bourdeau, V., Baudry, D. and Ferbeyre, G. (2009). PML links aberrant cytokine signaling and oncogenic stress to cellular senescence. Frontiers in Bioscience 14, 475-485.
  • Gendron K, Charbonneau J, Dulude D, Heveker N, Ferbeyre G*, Brakier-Gingras L*. (2008). The presence of the TAR RNA structure alters the programmed -1 ribosomal frameshift efficiency of the human immunodeficiency virus type 1 (HIV-1) by modifying the rate of translation initiation. Nucleic Acids Res. 36(1):30-40. *corresponding authors
  • Mallette FA, Ferbeyre G. The DNA damage response contributes to tumor suppression by sensing oncogenic activity. Med Sci (Paris). 2008 Jan;24(1):29-30. French.
  • Mallette, F.A., Gaumont-Leclerc, MF. and Ferbeyre, G. (2007). MYC downregulation as a mechanism to activate the RB pathway in STAT5A-induced senescence. J. Biol Chem. 282(48):34938-44. (published on line October 3, 2007)
  • Villiard E, Brinkmann H, Moiseeva O, Mallette FA, Ferbeyre G*, Roy S*. (2007) Urodele p53 tolerates amino acid changes found in p53 variants linked to human cancer. BMC Evol Biol. 7(1):180. *corresponding authors
  • Mallette, F.A. and Ferbeyre, G. (2007). The DNA Damage Signaling Pathway Connects Oncogenic Stress to Cellular Senescence. Cell Cycle 6(15), 1831 - 1836.
  • Ferbeyre G. (2007) Barriers to Ras transformation. Nat Cell Biol. 9(5):483-5.
  • Sylvestre Y, De Guire V, Querido E, Mukhopadhyay UK, Bourdeau V, Major F, Ferbeyre G*, Chartrand, P*. (2007). An E2F/miR-20a auto-regulatory feed-back loop. J Biol. Chem. 282:2135-43.*corresponding authors
  • Mallette, F.A., Gaumont-Leclerc, M.F., and Ferbeyre, G. (2007) The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence. Genes and Dev. 21:43-8.
    Roux AE, Quissac A, Chartrand P*, Ferbeyre G*, Rokeach LA*. (2006) Regulation of chronological aging in Schizosaccharomyces pombe by the protein kinases Pka1 and Sck2. Aging Cell. 5:345-57.*corresponding authors

    Moiseeva, O., Mallette, FA, Mukhopadhyay, UK.,Moores, A. and Ferbeyre, G. (2006) DNA damage signaling and p53-dependent senescence after prolonged β-interferon stimulation. Mol Biol Cell17:1583-92.
  • Mukhopadhyay UK, Senderowicz AM, Ferbeyre G. (2005). RNA silencing of checkpoint regulators sensitizes p53-defective prostate cancer cells to chemotherapy while sparing normal cells. Cancer Res. 65:2872-81.
  • Gendron K, Dulude D, Lemay G, Ferbeyre G, Brakier-Gingras L. (2005). The virion-associated Gag-Pol is decreased in chimeric Moloney murine leukemia viruses in which the readthrough region is replaced by the frameshift region of the human immunodeficiency virus type 1. Virology. 334:342-52.
  • Gaumont-Leclerc MF, Mukhopadhyay UK., Goumard S. and Ferbeyre G. (2004). PEA-15 is inhibited by adenovirus E1A and plays a role in ERK nuclear export and Ras-induced senescence. J Biol Chem. 279: 46802-46809.
  • de Stanchina, E., E. Querido, M. Narita, R.V.Davuluri, P.P. Pandolfi, G. Ferbeyre and S. W. Lowe. (2004). PML as a direct p53 target that modulates p53 effector functions. Mol Cell: 13:523-535.
  • Mallette, F.A*. Goumard, S*, Gaumont-Leclerc, M.F., Moiseeva, O and Ferbeyre, G. (2004). Human fibroblasts require the Rb family of tumor suppressors but not p53 for PML-induced senescence. Oncogene 23: 91-99.
  • Ferbeyre, G. (2002). PML a target of translocations in APL is a regulator of cellular senescence. Leukemia 16: 1918-1926.
  • Ferbeyre, G., E. de Stanchina, A. Lin, E. Querido, M. McCurrac, G. Hannon, and S. W. Lowe. (2002). Oncogenic ras and p53 cooperate to induce cellular senescence. Mol. Cell. Biol. 22: 3497-3508.
  • Ferbeyre, G. and Lowe S.W. (2002). Ageing: the price of tumor suppression? Nature 415:26-27.

Dernière mise à jour: 22/03/2006 © 2006 Gerardo Ferbeyre, site réalisé par Valentin Guignon