Andreea R. Schmitzer
EDUCATION
• Post-Doctoral: Université de Montréal, Montréal, Canada National Cancer Institute of Canada Post Doctoral Fellow Supervisor: Professor Joelle N. Pelletier November 2000 – August 2003
• Ph.D.: Université Paul Sabatier, Toulouse, France Supervisor: Professor Isabelle Rico-Lattes September 1997 – November 2000
• M.Sc.: Ecole Nationale Supérieure de Chimie de Toulouse, France (Institut National Polytechnique) – Organic Chemistry 1997
• Engineer Degree: Polytechnic University of Bucharest, Romania – Organic Chemistry 1992- 1997
awards and prizes
• Fellow of the Royal Society of Chemistry 2018
• Thieme Chemistry Journals Award 2011 • CNC IUPAC Travel Award 2007 • Ichikizaki Fund for Young Chemists awarded in 2005, 2006 and 2007 • FQRNT Faculty Award (Fonds Québécois pour la Recherche en Nature et Technologies) 2003-2008 National Cancer Institute of Canada Postdoctoral Fellowship 2003-2008 • Association des Universités Francophones –Postdoctoral Excellence Fellowship 2000-2001 • Ministère de l’Education du Québec – Postdoctoral Fellowship (declined) 2000 • Doctoral Research Scholarship – Ministère des Affaires Etrangères, France 1997-2000 • National Sigma-Aldrich-SFC prize (France) – Organic chemistry, 1st prize doctoral research, awarded for excellence in doctoral research 2001 • Regional Doctoral prize 2000 - Société française de chimie Section Midi-Pyrénées • Graduate Scholarship 1992-1997 • Polytechnic University of Bucharest Excellence Scholarship 1996-1997
Recent research support
• CIHR/Canadian Cancer Society: Team Grant (PI, with G. Ferbeyre) 2017-2019
• FRQNT : Team Grant (PI, with G. Ferbeyre and P. Chaurand) 2017-2020 • FRQNT: Strategic Grant "Centre en chimie verte et catalyse" (CGCC) (PI AB Charrette and CJ Li, with 42 others 2013-2017 • NSERC: Discovery Grant 2016-2021 • FRQNT : Team Grant (PI, with S.K. Collins and D. Rocheford) 2011-2014 • FRQNT : Team Grant (PI Pierre Chaurand , with J.F. Masson) 2011-2014 • NSERC: ENGAGE 2011 • FQRNT : Team Grant (PI, with J.F. Masson and G. Cosa) 2010-2013Recent Publications
2020
88. P. Beauclair, S. Fortun, A.R. Schmitzer (2020) "Structural Features Influencing the Activity of Bis-biguanide Ligands in the Suzuki-Miyaura Cross-Coupling Reaction in Neat Water." Accepté, Can. J. Chem. https://doi.org/10.1139/cjc-2020-0033 ($ NSERC)
87. L. Leclercq, J. Tessier, G. Douyere, V. Nardello-Rataj, A.R. Schmitzer (2020) "Phytochemicals and cyclodextrins based- Pickering emulsions: natural potentiators of antibacterial, antifungal and antibiofilm activity" Langmuir, 36, 16, 4317–4323 ($ NSERC))
86. J. Tessier and A.R. Schmitzer* (2020) "Benzimidazolium salts prevent and disrupt methicillin-resistant Staphylococcus aureus biofilms", RSC Adv., 10, 9420-9430 ($ NSERC)
85. S. Fortun and A.R. Schmitzer* (2020) "The chemistry of biguanides: from synthetic routes to applications in organic chemistry", Can. J. Chem., 98(6): 251-260 ($ NSERC)
84. A. Hebert, M. Parisotto, M.C. Rowell, A. Dore, A. Fernandez, G. Lefrancois, P. Kalegari, G. Ferbeyre, A.R. Schmitzer* (2019) "Phenylethynylbenzyl-Modified Biguanides Inhibit Pancreatic Cancer Tumor Growth", http://biorxiv.org/cgi/content/short/793109v1
2018
83. V. Gauchot, A. R. Schmitzer. (2018). "Organocatalysis induced by the anion of an ionic liquid: a new strategy for asymmetric ion-pair catalysis. Ed. Scott Handy. Organocatalysis in Ionic Liquids. (chapter 3), 234-254. ($ NERC)
82. J. Tessier, M. Lecluse, J. Gravel, A. R. Schmitzer. (2018). "Antimicrobial and Antibiofilm Activity of Disubstituted Bis-benzimidazolium Salts". Chem.Med.Chem., in press ($ NERC)
81. G. Ferbeyre, M. Parisotto, M.-C. Rowell, V. Bourdeau, A. R. Schmitzer. (2018). Pharmacologic inhibition of NAMPT sensitizes pancreatic cancer cells to the antineoplastic effects of metformin. Proceedings of the American Association for Cancer Research Annual Meeting. 78(13)($ CIHR)
80. A. Hébert, M. Parisotto, G. Ferbeyre, A. R. Schmitzer. (2018). Membrane permeabilization and perturbation induced by alkylbiguanidium salts. Supramolecular chemistry ($ CIHR)
79. J. Tessier, M. Golmohamadi, K. J. Wilkinson, A. R. Schmitzer (2018) "Anti-staphylococcal biofilm activity of miconazoctylium bromide" Org. Biomol. Chem., 16, 4288-4294 ($ NSERC)
78. S. Fortun, A.R. Schmitzer* (2018) "Metformin as a versatile ligand for recyclable palladium-catalyzed cross-coupling reactions in neat water" ACS Omega, 3, 1889-1896. ($ NSERC)
2017
77. T. Brulé, G. Granger, N. Bukar, C. Deschênes-Rancourt, T. Havard, A. R. Schmitzer, R. Martel, J.F. Masson (2017) "Field-deployed surface plasmon resonance (SPR) sensor for RDX quantification in environmental waters" Analyst accepted ($ NSERC)
76. A. Aubé, S. Campbell, A.R. Schmitzer, A. Claing, J.F. Masson (2017) "Ultra-low fouling alkylimidazolium modified surfaces for the detection of HER2 in breast cancer cell lysate" Analyst accepted ($ NSERC)
75. J. L. Toulouse, S. M. J. Abraham, N. Kadnikova, D. Bastien, V. Gauchot, A.R. Schmitzer, J.N. Pelletier* (2017) "Investigation of classical organic and ionic liquid co-solvents for early stage screening in fragment-based inhibitor design with unrelated bacterial and human dihydrofolate reductases", Assay and Drug Development Technologies accepted. ($ NSERC)
74. J. Kempf, A.R. Schmitzer* (2017) "Metal-organic synthetic transporters (MOST): efficient chloride and antibiotic transmembrane transporters", accepted Chemistry: European Journal. ($ NSERC)
73. T.D. Do, M. Anouti, D. Rocheford, A.R. Schmitzer* (2017) " Seedless synthesis of anisotropic gold nanoparticles using ionic liquids/dimethylformamide binary mixtures at room temperature" submitted ($ NSERC)
72. J. Gravel, C. Paradis-Bleau, A.R. Schmitzer* (2017) "Revisiting a bacterial membrane permeabilization assay for quantitative evaluation of a membrane disrupting agent" Medicinal Chemistry Communications accepted ($ NSERC)
71. S. Fortun, P. Beauclair, A.R. Schmitzer* (2017) "Metformin as a versatile ligand for recyclable palladium-catalyzed cross-coupling reactions in neat water" RSC Advances accepted. ($ NSERC)
70. J. Gravel, A.R. Schmitzer* (2017) "Imidazolium and benzimidazolium-containing compounds: from simple toxic salts to highly bioactive drugs" Organic and Bioorganic Chemistry 15, 1051–1071. ($ NSERC)
2016
69. T.D. Do, A.R. Schmitzer* (2016) " Highly Ordered Rectangular Columnar Ionic Liquid Crystals: A More Efficient Medium for Intramolecular Diels Alder Reactions" ($ NSERC) Chemistry Select, accepted. ($ NSERC)
68. J. Gravel, E.R. Elie, M. Khayat, A.R. Schmitzer* (2016) "Host-Guest Strategy to Potently Camouflage And Restore the Activity And Toxicity of Drugs Affecting Bacterial Growth and Viability" ChemMedComm. 7,1128–1131. ($ NSERC)
67. J. Kempf, A.R. Schmitzer* (2016) "Membrane active cationic cholic acid-based molecular umbrellas", RSC Advances 6 (48), 42713-42719. ($ NSERC)
2015
66. J. Gravel, J. Kempf, A.R. Schmitzer* (2015) " Host-Guest Strategy to Reversibly Control a Chloride Carrier Process with Cyclodextrins " Chemistry European Journal 21 (51), 18642-18648. ($ NSERC)
65. V. Gauchot, J. Gravel, M. Vidal, M. Charbonneau, V. Kairouz, A.R. Schmitzer*(2015) “Imidazolium and Benzimidazolium Salts: A Veritable Playground for Organic and Supramolecular Chemists” SYNLETT 26 (20), 2763-2779($ NSERC)
64. C.-R. Elie, G.David, A.R. Schmitzer* (2015)"Strong antibacterial properties of anion transporters: a result of depolarization and weakening of the bacterial membrane" Journal of Medicinal Chemistry, 58 (5), 2358-2366. ($ NSERC)
63. T.D. Do, A.R. Schmitzer* (2015) "Intramolecular Diels Alder reactions in highly organized imidazolium salts-based ionic liquid crystals" ($ NSERC) RSC Advances, 5, 635-639. ($ NSERC)
62. M.C. Ebert, K.L. Morley, J. Volpato, A.R. Schmitzer, J.N. Pelletier* (2015) "Asymmetric mutations in the tetrameric R67 DHFR reveal high tolerance to active-site substitutions" Protein Science 24 (4), 495-507.
61. J. Gravel, A.R. Schmitzer* (2015) "Transmembrane Anion Transport Mediated by Adamantyl-functionalized Imidazolium Salts" Supramolecular Chemistry 27 (5-6), 364-371. ($ NSERC).
2014
60. L. Leclercq, A.R. Schmitzer* (2014) "The Liquid Crystal State: An Intermediate State to Obtain Crystal Packing" Journal of Molecular Liquids 10, 200-283.
59. M. Charbonneau, G. Addoumieh, P. Oguadinma (2014) "Support-free palladium-NHC catalyst for highly recyclable heterogeneous Suzuki-Miyaura coupling in neat water" Organometallics 33 (22), 6544-6549($ NSERC)
58. J. Kempf, N. Noujeim, A.R. Schmitzer* (2014) "2,4,7-triphenylbenzimidazole: the monomeric unit of supramolecular helical rod-like transmembrane transporters", 4 (80), 42293-42298. ($ NSERC)
57. M. Vidal, A.R. Schmitzer* (2014) "Molecular parameters and transmembrane transport mechanism of imidazolium-functionnalized binols", Chemistry: European Journal, 20, 9998-10004. ($ NSERC)
56. V. Kairouz, A.R. Schmitzer* (2014) "Imidazolium-functionalized β-cyclodextrin as highly recyclable multifunctional ligand in water", Green Chem, 6, 3117-3124. ($ NSERC, CCVC)
55. M. Vidal, A.R. Schmitzer* (2014)"Thermophysical properties of imidazolium-functionalized binols and their application in asymmetric catalysis", Organometallics, 33 (13), 3328-3340. ($ NSERC)
54. V. Gauchot, A.R. Schmitzer* (2014) "Catalytic anions embedded into avidin: importance of their chirality and the chiral environment on the stereocontrol of the aldol reaction", Journal of the Organic Chemistry, 79, 2694-2701. ($ NSERC)
53. M. Vidal, C.R. Elie, S. Campbell, A. Claing, A.R. Schmitzer, (2014) "Biologically active binaphthol-scaffolded imidazolium salts" Medicinal Chemistry Communications 5, 436-441. ($ NSERC)
52. C-R. Elie, M. Vidal, M. Charbonneau, A. Hébert, A.R. Schmitzer* (2014) "Biologically active synthetic anion transporters", Current Organic Chemistry, 18 (11), 1875-5348. ($ NSERC)
51. V. Gauchot, M. Branca, A.R. Schmitzer* (2014) "Merging an achiral anionic organocatalyst and a chiral protein environment", Chemistry: European Journal, 20 (6), 1530-1538. (highlight) ($ NSERC)