Université de Montréal     Faculté de médecine       Département de pharmacologie      Neurosciences


Publications

 Trudeau L-E, Hnasko TS, Wallén-Mackenzie A, Morales M, Rayport S, Sulzer D (2014) The multilingual nature of dopamine neurons. Prog. Brain Res. 211: 141-164.

Sanchez G., Varaschin RK, Bueler H, Marcogliese PC, Park DS, Trudeau L-E (2014) Unimpaired striatal dopamine release in juvenile Parkin knockout, Pink1 knockout, DJ-1 knockout and LRRK2 R1441G transgenic mice PloS One 9(4): e94826.

Charfi I, Nagi K, Mnie-Filali O, Thibault D, Balboni G, Schiller PW, Trudeau L-E, Pineyro G (2014) Ligand and cell-dependent determinants of internalization and cAMP modulation by delta opioid receptor (DOR) agonists. Cell. Mol. Life Sci. 71(8):1529-46.

Poliquin PO, Chen J, Cloutier M, Trudeau L-E, Jolicoeur M (2013) Metabolomics and in-silico analysis reveal critical energy deregulations in animal models of Parkinson’s disease. PLoS One, 8(7): e69146.

Thibault D, Loustalot F, Fortin GM, Bourque MJ, Trudeau L-E (2013) Evaluation of D1 and D2 dopamine receptor segregation in the developing striatum using BAC transgenic mice. PLoS One, 8(7): e67219.

Fasano C, Bourque MJ, Lapointe G, Leo D, Haber M, Kortleven C, Desgroseillers L, Murai K, Trudeau L-E (2013) Dopamine facilitates dendritic spine formation by cultured striatal medium spiny neurons through both D1 and D2 dopamine receptors. Neuropharmacology 67:432-443.

Hernandez-Blatazar D, Martinez-Fong D, Trudeau L-E (2012) Optimizing NTS-Polyplex as a tool for gene transfer to cultured dopamine neurons. PLOS One 7(12): e51341.

 Fortin GM, Bourque MJ, Mendez JA, Leo D, Nordenankar K, Birgner C, Arvidsson E, Rymar VV, Bérubé-Carière N, Claveau AN, Descarries L, Sadikot AF, Wallen-Mackenzie A, Trudeau L-E. (2012) Glutamate corelease promotes growth and survival of midbrain dopamine neurons. Journal of Neuroscience, 32(48) : 17447-17492.

Kortleven C, Bruneau LC, Trudeau L-E. (2012) Neurotensin inhibits glutamate-mediated synaptic inputs onto ventral tegmental area dopamine neurons through the release of the endocannabinoid 2-AG. Neuropharmacology, 63(6):983-91.

Martinez-Fong D, Bannon MJ, Trudeau L-E, Gonzalez-Barrios JA, Arango-Rodriguez ML, Hernandez-Chan NG, Reyes-Corona D, Armendáriz-Borunda J Navarro-Quiroga I (2012) NTS-polyplex: A potential nanocarrier for neurotrophic therapy of Parkinson’s disease. Nanomedicine: Nanotechnology, Biology, and Medicine, 8(7):1052-69. Article en format PDF.

Bérubé-Carrière N, Guay G, Fortin GM, Kullander K, Olson L, Wallen-Mackenzie A, Trudeau, L-E, Descarries L. (2012) Ultrastructural characterization of the mesostriatal dopamine innervation in mice, including two mouse lines of conditional VGLUT2 knockout in dopamine neurons. European Journal of Neuroscience, 35(4):527-538. Article en format PDF.

Alsiö J, Nordenankar K, Arvidsson E, Birgner C, Mahmoudi S, Halbout B, Smith C, Fortin GM, Olson L, Descarries L, Trudeau LE, Kullander K, Lévesque D, Wallén-Mackenzie A. (2011) Enhanced Sucrose and Cocaine Self-Administration and Cue-Induced Drug Seeking after Loss of VGLUT2 in Midbrain Dopamine Neurons in Mice. Journal of Neuroscience 31(35):12593-12603. Article en format PDF.

Martel P, Leo D, Fulton S, Bérard M, Trudeau LE. (2011) Role of kv1 potassium channels in regulating dopamine release and presynaptic d2 receptor function. PLoS One. 6(5):e20402. Article en format PDF.

El Mestikawy, S., Wallen-Mackenzie, A., Fortin, G., Descarries, L., Trudeau, L.-E. (2011) From glutamate corelease to vesicular synergy: new perspectives on the functions of vesicular glutamate transporters. Nature Reviews Neuroscience 12(4):204-16. Article en format PDF.

Kortleven C, Fasano C, Kortleven C, Lacaille JC and Trudeau, L-E (2011)  The endocannabinoid 2-Arachidonoylglycerol inhibits long-term potentiation of glutamatergic synapses onto ventral tegmental area dopamine neurons in mice. European Journal of Neuroscience 33(10):1751-60. Article en format PDF.

Fulton, S, Thibault., D., Mendez, J.A., Lahaie, N., Tirotta, E., Borrelli, E., Bouvier, M., Tempel, B, Trudeau, L.-E. (2011) Contribution of Kv1.1 and 1.2 voltage-gated potassium channels to D2 autoreceptor regulation of axonal dopamine overflow. Journal of Biological Chemistry 286(11):9360-72. Article en format PDF.

Thibault D, Albert, PR, Pineyro G and Trudeau L-E (2011) Neurotensin triggers D2 dopamine receptor desensitization through a PKC and beta-arrestin1-dependent mechanism. Journal of Biological Chemistry 286(11):9174-84. Article en format PDF.

Drouin-Ouellet J, Brownell AL, Saint-Pierre M, Fasano C, Vincent E, Trudeau L-E, Lévesque D, Cicchetti F (2010) Neuroinflammation is associated with changes in glial mGluR5 expression and the development of neonatal excitotoxic lesions. Glia 59(2):188-99. Article en format PDF.

Fasano, C., Kortleven, C., Trudeau, L.-E. (2010) Chronic activation of the D2 autoreceptor inhibits both glutamate and dopamine synapse formation and alters the intrinsic properties of mesencephalic dopamine neurons in vitro. European Journal of Neuroscience 32(9):1433-41. Article en format PDF.

Xu, B., Goldman. J.S., Rymar, V.V., Forget, C., Lo, P.S., Bull, S.-J., Vereker, E., Barker, P.A., Trudeau, L.-E., Sadikot, A.F., Kennedy, T.E. (2010) Critical Roles for the Netrin Receptor DCC in Dopaminergic Neuronal Precursor Migration, Axon Guidance, and Axon Arborization. Neuroscience 169(2):932-949. Article en format PDF.

Birgner C, Nordenankar K, Lundblad M, Mendez JA, Smith C, le Grevès M, Galter D, Olson L, Fredriksson A, Trudeau L.-E, Kullander K, Wallén-Mackenzie A. (2010) VGLUT2 in dopamine neurons is required for psychostimulant-induced behavioral activation. Proc Natl Acad Sci U S A. 107(1):389-94. Article en format PDF.

Thibault, D., Kortleven, C., Fasano, C., Dal Bo, G., Trudeau, L.-E. (2010) Découvertes récentes sur la fonction et la plasticité des voies dopaminergiques du cerveau. Médecine/Sciences 26 : 165-170. Article en format PDF.

Bérubé-Carrière, N., Riad, M., Dal Bo G., Lévesque, D., Trudeau, L.-E., Descarries, L. (2009) The dual dopamine-glutamate phenotype of growing mesencephalic neurons regresses in mature rat brain. J. Comp. Neurol. 517(6):873-91. Article en format PDF.

Fawaz, C.S., Martel, P., Leo, D., Trudeau, L.-E. (2009) Presynaptic action of neurotensin on dopamine release through inhibition of D2 receptor function. BMC Neuroscience 10(1): 96 (open access article). Article en format PDF.

Trudeau, L.-E., Dal Bo, G., Mendez, J. A. (2009) Glutamate co-release by monoamine neurons. In Co-existence and co-release of classical neurotransmitters. Gutierrez R (Ed), Springer, New York, pp. 127-144.

Descarries, L., Bérubé-Carrière, N., Riad, M., Dal Bo, G., Mendez, J.A. Trudeau, L.-É. (2008) Glutamate in dopamine neurons: synaptic versus diffuse transmission. In: Communication and Integration in the Basal Ganglia, K. Fuxe, L.F. Agnati, F. Mora and R. Schwarcz Eds. Brain Res. Rev. 58: 290-302. Article en format PDF.

Fasano, C., Poirier, A., Desgroseillers, L., Trudeau, L.-E. (2008) Chronic activation of the D2 dopamine autoreceptor inhibits synaptogenesis in mesencephalic dopaminergic neurons in vitro. Eur. J. Neurosci. 28: 1480-1490. Article en format PDF.

Sulzer D, Trudeau L.-E, Rayport S (2008) Postnatally derived ventral midbrain dopamine neuron cultures as a model system for studying neurotoxicity and Parkinson’s disease. In Parkinson’s Disease: Molecular and Therapeutic Insights from Model Systems. Nass R (Ed), Academic Press, Burlington, MA, pp. 491-504.

Dal Bo, G., Bérubé-Carrières, N., Mendez, J.A., Riad, M., Descarries, L., Lévesque, D., Trudeau, L.-E. (2008) The glutamatergic phenotype of mesencephalic dopamine neurons is enhanced following a neonatal 6-hydroxydopamine lesion. Neuroscience, 156(1): 59-70. Article en format PDF.

Mendez JA, Bourque MJ, Dal Bo G, Bourdeau ML, Danik M, Williams S, Lacaille JC, Trudeau L-E (2008) Developmental and target-dependent regulation of vesicular glutamate transporter expression by dopamine neurons. Journal of Neuroscience 28(25):6309-6318. Article en format PDF.

Fasano C, Thibault D, Trudeau L-E (2008) Culture of postnatal mesencephalic dopamine neurons on an astrocyte monolayer. Current Protocols in Neuroscience  July; Chapter 3:Unit 3.21

Huh CY, Danik M, Manseau F, Trudeau L-E, Williams S. (2008) Chronic exposure to nerve growth factor increases acetylcholine and glutamate release from cholinergic neurons of the rat medial septum and diagonal band of Broca via mechanisms mediated by p75NTR. Journal of Neuroscience 28(6):1404-1409. Article en format PDF.

Descarries, L., Bérubé-Carrière, N., Riad, M., Dal Bo, G., Mendez, J.A., Trudeau, L.-E. (2008) Glutamate in dopamine neurons : synaptic versus diffuse transmission. Brain Research Reviews 58(2): 290-302. Article in PDF format.

Trudeau, L.-E (2007) Antipsychotiques, dopamine et glutamate, une relation à établir. Santé Mentale au Québec 32: 191-199. Article en format PDF.

Trudeau, L.-E. et Gutierrez, R. (2007) On cotransmission and neurotransmitter phenotype plasticity. Molecular Interventions 7(3) : 138-146. Article en format PDF.

Jomphe, C., Lemelin, P.-L., Okano, H., Kobayashi, K. et Trudeau, L.-E. (2006)  Bidirectional regulation of dopamine D2 and neurotensin NTS1 receptors in
dopamine neurons. European Journal of Neuroscience 24(10): 2789-2800. Article en format PDF.

Gonzalez-Barrios, J.A., Lindahl, M, Bannon, M.J., Anaya-Martınez, V, Flores, G. Navarro-Quiroga,I,  Trudeau, L.-E., Aceves, J., Martinez-Arguelles, D.B., Garcia-Villegas, R., Jimenez,I., Segovia, J. and Martinez-Fong, D. (2006). Neurotensin polyplex as an efficient carrier for delivering the human GDNF gene into nigral dopamine neurons of hemiparkinsonian rats. Molecular Therapy 14(6): 857-865.  Article en format PDF.

St-Gelais, F., Jomphe, C. et Trudeau, L.-E. (2006) Role of neurotensin in CNS pathophysiology: what is the evidence? Journal of Psychiatry and
Neuroscience
31: 229-245. Article en format PDF.

Forget, C., Stewart, J. et Trudeau, L.-E. (2006) Impact of basic FGF expression in astrocytes on dopamine neuron synaptic function and development. European Journal of Neuroscience 23: 608-616. Article en format PDF.

Fortin, G.D., Desrosiers, C.C., Yamaguchi, N., et Trudeau, L.-E. (2006) Basal somatodendritic dopamine release requires SNARE proteins. Journal of Neurochemistry 96: 1740-1749. Article en format PDF.

Jomphe, C., Tiberi, M. et Trudeau, L.-E. (2006) Expression of D2 receptor isoforms in cultured neurons reveals equipotent autoreceptor function. Neuropharmacology 50: 595-605. Article en format PDF.

Jomphe, C., Bourque, M.J., Fortin, G., St-Gelais, F., Okano, H., Kobayashi, K. et Trudeau, L.-E. (2005) Use of TH-GFP transgenic mice as a source of identified dopaminergic neurons for physiological studies in postnatal cell culture. Journal of Neuroscience Methods 146: 1-12. Article en format PDF.

Drapeau, J., El-Helou, V., Clement, R., Bel-Hadj, S., Gosselin, H., Trudeau L.-E., Villeneuve, L. et Calderone, A. (2005) Nestin-expressing neural stem cells identified in the scar following myocardial infarction. J Cell Physiol. 204: 51-62. Article en format PDF.

Michel, F.J., Fortin, G., Martel, P., Yeomans, J et Trudeau, L.-E. (2005) M3-muscarinic receptors mediate Ca2+ influx in rat mesencephalic GABAergic neurones through a protein kinase C-dependent mechanism. Neuropharmacology 48(6): 796-809. Article en format PDF.

Croft, B.G., Fortin, G., Corera, A.T., Edwards, R.H. , Beaudet, A., Trudeau, L.-E. et Fon, E.A. (2005) Normal Biogenesis and Cycling of Synaptic Vesicles in Dopamine Neurons of Vesicular Monoamine Transporter 2 Knockout Mice. Molecular Biology of the Cell 16: 306-315. Article en format PDF.

Trudeau, L.-E. (2004) Glutamate co-transmission as an emerging concept in monoamine neuron function. Journal of Psychiatry and Neuroscience 29: 296-310. Article en format PDF.

St-Gelais, F., Ménard, C., Congar, P., Trudeau, L.-E. et Massicotte, G. (2004) Postsynaptic injection of calcium-independent phospholipase A2 inhibitors selectively increases AMPA receptor-mediated synaptic transmission. Hippocampus 14: 319-325. Article en format PDF.

Michel, F.J., Robillard, J.M. et Trudeau, L.-E. (2004) Regulation of rat mesencephalic GABAergic neurons through muscarinic receptors. Journal of Physiology 556(2): 429-445. Article en format PDF. 

St-Gelais, F., Legault, M., Rompré, P.-P. et Trudeau, L.-E. (2004) Role of calcium in neurotensin-evoked enhancement in firing in mesencephalic dopamine neurons. Journal of Neuroscience 24: 2566-2574. Article en format PDF.

Dal Bo, G., St-Gelais, F., Danik, M., Williams, S., Cotton, M. et Trudeau, L.-E. (2004) Dopamine neurons in culture express VGLUT2 explaining their capacity to release glutamate at synapses in addition to dopamine. Journal of Neurochemistry 88: 1398-1405. Article en format PDF.

Jomphe, C, Lévesque, D et Trudeau, L.-E. (2003) Calcium-dependent, D2 receptor-independent induction of c-fos by haloperidol in cultured dopamine neurons. Naunyn-Schmiedeberg’s Archives of Pharmacology 367: 480-489. Article en format PDF.

Congar, P. et Trudeau, L.-E. (2002) Perturbation of synaptic vesicle delivery during neurotransmitter release triggered independently of calcium influx. Journal of Physiology 542: 779-793. Article en format PDF.

Bergevin, A., Girardot, D. Bourque, M.-J. et Trudeau, L.-E. (2002) Presynaptic µ-opioid Receptors Regulate a Late Step of the Secretory Process in Rat Ventral Tegmental Area GABAergic Neurons. Neuropharmacology 42:1065-1078. Article en format PDF

Galarneau, A, Primeau, M., Trudeau, L.-E. et Michnick, S.W. (2002) Beta-Lactamase Protein fragment Complementation Assays as in vivo and in vitro Sensors of Protein-Protein Interactions. Nature Biotechnology 20:619-622. Article en format PDF.

Legault, M., Congar, P., Michel, F.J. et Trudeau, L.-E. (2002) Presynaptic action of neurotensin on cultured ventral tegmental area dopaminergic neurones. Neuroscience 111:177-187. Article en format PDF.

Congar, P., Bergevin, A et Trudeau, L.-E. (2002) D2 Receptors Inhibit the Secretory Process Downstream From Calcium Influx in Dopaminergic Neurons: Implication of K+ Channels. Journal of Neurophysiology 87:1046-1056. Article en format PDF

Bourque, M.-J. and Trudeau, L.-E. (2000) GDNF enhances the synaptic efficacy of dopaminergic neurons in culture. European Journal of Neuroscience 12:3172-3181. Article en format PDF    (Éditeur: Blackwell Science/EJN)

Trudeau, L.-E. (2000) Activation of ventral tegmental area astrocytes by
neurotensin: evidence for the involvement of multiple receptors Neuroscience 97: 293-302.  Article en format PDF

Michel, F.J. and Trudeau, L.-E. (2000) Clozapine inhibits synaptic transmission at GABAergic synapses established by ventral tegmental area neurones in culture. Neuropharmacology 39: 1536-1543. Article en format PDF

Trudeau, L.-E., Parpura, V.P. and Haydon, P.G. (1999) Activation of neurotransmitter release in hippocampal nerve terminals during recovery from intracellular acidification. Journal of Neurophysiology 81: 2627-2635.  Article en format PDF

Trudeau, L.-É., Fang, Y. and Haydon, P.G. (1998) Modulation of an early step in the secretory machinery in hippocampal nerve terminals Proceedings of the National Academy of Sciences USA 95: 7163-7168.  Article en format PDF

Bahls, F.H., Lartius, R.K., Trudeau, L.-E., Doyle, R.T., Fang, Y., Witcher, D.R., Campbell, K.P. and Haydon, P.G. (1998) Contact dependent regulation of N-type calcium channel subunits during synaptogenesis. Journal of  Neurobiology 35: 198-208.  Article en format PDF

Haydon, P.G. and Trudeau, L.-É. (1998) Regulatory roles for GTP-binding proteins in nerve terminals. Seminars in Neuroscience 9: 220-231.

Trudeau, L.-É., Emery, D.G., and Haydon, P.G. (1996) Direct modulation of the secretory machinery underlies PKA-dependent synaptic facilitation in hippocampal neurons. Neuron 17 :789-797.  Article en format PDF

Trudeau, L.-É. , Doyle, R.T., Emery, D.G. and Haydon, P.G. (1996) Calcium-independent activation of the secretory apparatus by ruthenium red in hippocampal neurons: a new tool to assess modulation of presynaptic function. J.Neurosci. 16: 46-54. Article en format PDF

 

Publications antérieures